How do I manage diarrhea in my patients taking ixazomib?

Clinical Pearls Podcasts published on January 30, 2017
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R. Donald Harvey III, PharmD, FCCP, BCOP
Director, Phase I Program, Winship Cancer Institute
Assistant Professor, Hematology/Medical Oncology
Emory University School of Medicine
Atlanta, Georgia
How do I manage diarrhea in my patients taking ixazomib?
Hi, my name is Dr. Donald Harvey. I am Director of the Phase 1 Clinical Trial Section and an Associate Professor in Hematology, Medical Oncology, and Pharmacology at the Winship Cancer Institute of Emory University. To manage diarrhea in patients taking ixazomib, I would ensure that all patients have loperamide on hand at home before beginning ixazomib and that they understand that they can take multiple dosage of loperamide as needed. Patients need to get on top of diarrhea should it happen and need to get on top of it early so taking 4 mg at least every 2 to 4 hours as needed for diarrhea is important. When patients are diarrhea-free for 12 hours, they can then stop taking an anti-diarrheal medication. Occasionally, patients will not respond to loperamide and so giving them other agents like diphenoxylate with atropine may be helpful as well. For more multiple myeloma clinical pearls, please visit the MediCom Oncology Podcast Channel or ManagingMyeloma.com.

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Last modified: February 17, 2017
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